1. Use of serum creatinine concentration to assess -edited–

• Serum creatinine alone should not be used as a measure of kidney function as it is particularly insensitive for identifying chronic kidney disease (CKD) in its early-to-middle stages and in certain patient groups (e.g. small body size, females, elderly) when populationbased decision points are used. (Level III evidence, multiple large cohort studies in community and institutional settings, clinically relevant outcomes, strong effects)